Glycosylation of therapeutic proteins

Galić, Hrvoje (2012) Glycosylation of therapeutic proteins. Bachelor's thesis, Faculty of Science > Department of Biology.

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Many impressive achievements of therapeutic proteins in treating serious illnesses would not be possible without glycoengineering. Therapeutic proteins have a short serum half-life and limited biological activity. That is why it's necessary to include more glycosylation mechanisms which will consequentially enhance the pharmacokinetic and pharmacodynamic properties of therapeutic proteins. In this paper, the basic glycosylation principles in all domains of life are presented. A special emphasis was given to the importance of the glycosylation process itself on the stability, structure and function of (therapeutic) proteins. In more detail were explained the various methods of synthesis, the problem of glycosylation of human proteins in other organisms and various ways to obtain the wanted glycoform of a therapeutic protein. There were given many examples of in vivo enhancements of protein bioactivity via glycoengineering, from the hyperglycosylated analog of the human recombinant erythropoietin (NESP) to therapeutic antibodies and β-glucocerebrosidase.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Gruić Sovulj, Ita
Date: 2012
Number of Pages: 25
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 20 Oct 2014 11:55
Last Modified: 16 Feb 2016 13:56

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