RNA helicases

Kovačević, Alen (2012) RNA helicases. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

RNA helicases are highly conserved enzymes abundant in all three life domains and some viruses. These enzymes participate in all stages of RNA metabolism from transcription to degradation and are very effective in unwinding short dsRNAs, RNA-DNA heteroduplexes, remodeling RNA structure and removing RNAs from RNP complexes. All these functions are done in an ATP-dependent fashion. In this work, eucaryotic DEAD box RNA helicases are described in detail. Characteristic of all DEAD box proteins are two RecA-like domains which harbour RNA and ATP binding sites. These highly conserved enzymes in cooperation with other proteins can perform different functions such as the initiation of translation (eIF4A) and mRNA transport from nucleus to cytoplasm (Dbp5).

Item Type: Thesis (Bachelor's thesis)
Supervisor: Ivančić Baće, Ivana
Date: 2012
Number of Pages: 14
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 23 Oct 2014 11:00
Last Modified: 23 Oct 2014 11:00
URI: http://digre.pmf.unizg.hr/id/eprint/3142

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