UV-induced cancerogenesis in skin tumors

Jurlin, Jelena (2011) UV-induced cancerogenesis in skin tumors. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Skin cancer is one of the cancer types with the highest prevalence and its incidence is increasing in the world. The main cause of its occurrence is overexposure to UV radiation, due to lack of information about its harmfulness. Thinning of the ozone layer is the cause of more UV radiation reaching the Earth's surface, especially its harmful components UVA and UVB. Those two components induce skin damage by forming the pre-cancerous lesions such as cyclobutane pyrimidine dimers and 6,4-fotoproduct, by suppressing immune responses and causing oxidative damage to DNA molecules. If this damage is not repaired before DNA replication, it can result in uncontrolled growth and cell division of the cells in which the damage occurred, thus causing tumors. The tumor is usually easily noticeable, since it occurs in the outer layer of skin, so it can be diagnosed at an early stage and therefore be treated. There are several types of skin tumors, and not all are equally dangerous. The most dangerous type of skin cancer is melanoma, because of its ability to spread and invade the surrounding tissues. People with lighter pigmentation have higher risk of skin cancer due to lower amounts of melanin, which protects against UV radiation, as do people who have a genetic predisposition for developing this disease. There are several ways of preventing the development of this disease and they generally include reduced exposure to UV radiation by avoiding the sun between 10 am and 16 pm, wearing hats and sunglasses, staying in the shade and applying sunscreen with high sun protecting factor. Therefore, it is very important to educate people about the risks and hazards of the UV radiation in order to increase awareness of its dangers, and thus prevent the formation of skin cancer. Besides direct sun exposure, photo therapies and tanning salons increase risk of developing skin cancer, so their use should also be avoided.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Marijanović, Inga
Date: 2011
Number of Pages: 27
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 27 Oct 2014 12:19
Last Modified: 27 Oct 2014 12:19
URI: http://digre.pmf.unizg.hr/id/eprint/3180

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