p53 tumor suppresor gene

Pažur, Kristijan (2011) p53 tumor suppresor gene. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

p53 gene was discovered in 1979. as a first tumor suppressor gene. The main role of the p53 gene is to prevent tumors by responding to certain stimuli, such as DNA damage, hypoxia or oncogene activation in a way to stop cell division, to activate DNA repair enzymes or to induce apoptosis. Concentration in the cell is regulated by the MDM2 protein that modifies p53 (adds ubiquitin) flagging it for the degradation by proteosomes. p53 is a phosphoprotein of 53 kDa and the gene in humans is located on a short arm of chromosome 17. This gene belongs to a highly preserved gene family containing at least two more members, p63 and p73. Wild-type p53 protein contains 393 amino acids and contains several structural and functional areas: the N terminal end or TAD domain, a region rich in proline, central domain (DNA binding), a region that contains nuclear localization signal, oligomerization domain and C-terminal basic domain. p53 has an important role in reproduction because it controls the implantation of the embryo. Mutations in the p53 gene are responsible for most cancers in humans, such as brain tumors, lung, breast, colon, and malignant diseases of the hematopoietic system (lymphoma and leukemia). Today it is known that p53 is one of the most important tumor-suppressor genes and its mutations are responsible for over 50% of all newly established tumors.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Marijanović, Inga
Date: 2011
Number of Pages: 18
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 29 Oct 2014 09:59
Last Modified: 29 Oct 2014 09:59
URI: http://digre.pmf.unizg.hr/id/eprint/3212

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