Variability of major histocompatibility complex DQA and DQB class II genes in the striped dolphin (Stenella coeruleoalba) and risso's dolphin (Grampus griseus)

Pavlinec, Željko (2014) Variability of major histocompatibility complex DQA and DQB class II genes in the striped dolphin (Stenella coeruleoalba) and risso's dolphin (Grampus griseus). Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Major histocompatibility system (MHC) has a central role in the regulation of immune response. MHC diversity is essential for the survival of the species because it allows for the recognition of a wide spectrum of pathogens. That diversity evolved under selective pressure, so MHC genes can be used as markers for the study of adaptive evolution in populations or species. Striped dolphin (Stenella coeruleoalba) and Risso’s dolphin (Grampus griseus) are a part of the family Delphinidae, suborder Odontoceti, order Cetacea. Both species inhabit pelagic warm and temperate waters. The goal of this study was to determine the variability of MHC class II DQA and DQB genes in the striped dolphin and Risso’s dolphin. In tissue samples from 21 striped and eight Risso’s dolphins a total of 21 DQA and 21 DQB alleles were found, of which only three DQA alleles were known from previous studies. The number of unique alleles, as well as the calculated evolutionary distances show a high level of diversity in both species, while the rates of non-synonymous and synonymous substitutions indicate the maintenance of the diversity on both loci by positive selection.

Item Type: Thesis (Diploma thesis)
Keywords: Cetacea, MHC, positive selection, genetic variability, Mediterranean sea
Supervisor: Galov, Ana and Đuras, Martina
Co-supervisor: Arbanasić, Haidi
Date: 2014
Number of Pages: 44
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Nov 2014 10:39
Last Modified: 13 Nov 2014 10:39
URI: http://digre.pmf.unizg.hr/id/eprint/3254

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