Expression of the glycoprotein tenascin-C in the subplate zone of the medial part of the telencephalon during prenatal development of the human brain

Čolović, Ozren (2014) Expression of the glycoprotein tenascin-C in the subplate zone of the medial part of the telencephalon during prenatal development of the human brain. Diploma thesis, Faculty of Science > Department of Biology.

[img]
Preview
PDF
Language: Croatian

Download (945kB) | Preview

Abstract

The aim of this study was to describe the expression of the glycoprotein tenascin-C (TN-C) in the subplate zone (SP), in the period between gestation weeks (GW) 12 and 40, using the indirect immunohistochemistry method on postmortal brain tissue. The expression of TN-C starts in GW 16 in the deep SP and lasts up to GW 40. Its expression was not detected in the superficial portion of the SP. Apart from the SP, its expression is visible in the intermediate zone (IZ) and the cortical plate (CP). All three of the aforementioned zones show a fronto-occipital variation in TN-C expression. In GW 12 its expression was seen only in the IZ, and afterwards in all three zones in GW 16. In the frontal lobe TNC expression weakened by GW 20, and was either seen faintly, appearing sporadically, or was not detectable at all. It becomes clearly visible again in GW 25 and remains of weak intensity until the end of the gestation period. In central regions the expression is weak during the early and mid-fetal periods, but becomes moderate during the final period and is sustained until the end of gestation. Parietally the expression appears in the middle of the mid-fetal period and disappears by the late fetal period. The expression of TN-C did not correlate to the ingrowth of afferents from the thalamus and the basal forebrain. Its possible roles include autocrine stimulation of astrocyte and/or oligodendrocyte differentiation and proliferation, and axon guidance for subplate neurons projecting to the corpus callosum.

Item Type: Thesis (Diploma thesis)
Keywords: subplate, gestation, afferents, astrocytes, oligodendrocytes
Supervisor: Jovanov-Milošević, Nataša
Co-supervisor: Hranilović, Dubravka
Date: 2014
Number of Pages: 23
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Nov 2014 11:50
Last Modified: 13 Nov 2014 11:50
URI: http://digre.pmf.unizg.hr/id/eprint/3259

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata