Phytoestrogens and osteoporosis

Jakupić, Jelena (2014) Phytoestrogens and osteoporosis. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Impressive data from the many studies on cultured bone cells and various model organisms of postmenopausal simptoms and diseases like osteoporosis support a significant bone-sparing effect of soy phytoestrogens from the group of isoflavones (daidzein, genistein). Dietary phytoestrogens are natural plant substances with structure similar to 17-β-estradiol (female sex hormon) and capable of binding to estrogen receptors. Because of their structural similarity, phytoestrogens are able to act like estrogen and bind to estrogen receptors with higher affinity to ER-β than to ER-α. On that way, they contribute postmenopausal female health. In postmenopause estrogen concentration decreases causing many changes in organism and phytoestrogens are alternative estrogen. With other important factors, phytoestrogens prevent bone reabsorption and bone fracture. In plants, phytoestrogens are found as glucoconjugates, which are biologically inactive. By the action of intestinal bacteria (enzyme β-glukozidaza), they are hydrolyzed to active form (aglycon). These review focuses on the potential influence of phytoestrogens on bone bassed on many scientific research all over the world. Phytoestrogen biological activity is complex and the magnitude of the effect and the exact mechanism of action are not known yet. They are potential nutrients and dietary components that can influence bone health and some other diseases, but there is need for other researches to develop efficient and precocious strategies in the pervention of osteoporosis.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Oršolić, Nada
Date: 2014
Number of Pages: 13
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 Nov 2014 11:56
Last Modified: 13 Nov 2014 11:56
URI: http://digre.pmf.unizg.hr/id/eprint/3260

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