Mechanism of multixenobiotic resistance in bivalves (Bivalvia, Mollusca)

Cvitanić, Marija (2014) Mechanism of multixenobiotic resistance in bivalves (Bivalvia, Mollusca). Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Bivalves (Bivalvia) belong within phylum of mollusks (Mollusca). They are sedentary or half-sedentary aquatic organisms which feed by filtering water. Supply of water in their body brings oxygen and nutrients, also contaminants due to the aquatic environment. Animal itself possess numerous ways to throw those harmful substances out of the organism. One of those ways is mechanism of multixenobiotic resistance, shortened MXR mechanism. This mechanism consists of ABC transport proteins that transfer harmful substance from cytoplasm to extracellular fluid by using ATP molecules as energy source. However, MXR mechanism can be disrupted. There were found compounds which acts as an inhibitors of ABC transport proteins, the so-called chemosensitizers. Inhibition of MXR mechanism causes enormous accumulation of toxic substances in bivalve tissues (gills, digestive gland, gonads, etc.). If people consume these bivalves, poisoning will occur which can result in death. Therefore today in ecotoxicological laboratories around the world the MXR mechanism is studied. It is important to notice which substances act as chemosensitizers and at what concentrations in order to determine a range of allowed concentrations of these substances in water.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Lajtner, Jasna
Date: 2014
Number of Pages: 13
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 17 Nov 2014 11:03
Last Modified: 17 Nov 2014 11:03
URI: http://digre.pmf.unizg.hr/id/eprint/3282

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