Antioxidant status in plasma, erythrocytes and platelets following the use of antihemostatic drugs and vasodilatation supplements

Čolić, Ivan (2014) Antioxidant status in plasma, erythrocytes and platelets following the use of antihemostatic drugs and vasodilatation supplements. Diploma thesis, Faculty of Science > Department of Biology.

[img]
Preview
PDF
Language: Croatian

Download (659kB) | Preview

Abstract

The study monitored the changes in antioxidant status of plasma, platelets and red blood cells of rat blood after administration of antihemostatic drugs and vasodilating supplements alone and in combination. The experiment was composed of 9 groups under treatment and one control group. The groups under treatment were the groups: 1. Ginkgo, 2. Vulkan, 3. Salicilna, 4. Warfarin, 5. Vulkan+warfarin, 6. Vulkan+salicilna, 7. Ginko + warfarin, 8. Ginko + and 9. Ginkalert. Nine groups under treatment and the control group animals were treated over a period of 28 days, according to the recommended OECD 407 toxicological protocol. The animals were sacrificed and blood samples were taken. After centrifugation and separation of blood components the markers of antioxidant system, superoxide dismutase (SOD), glutathione (GSH), catalase (CAT) and malondialdehyde (MDA) were measured. This research has confirmed that there are a number of possible interactions between applying vasodilating supplements and antihemostatic drugs, which led to big changes in the antioxidant status of the organism. Obtained results suggest it is necessary to confine the simultaneous application of antihemostatic drugs and vasodilating supplements in order to prevent possible harmful effects.

Item Type: Thesis (Diploma thesis)
Keywords: ginkgo, warfarin, antioxidant, aspirin, SOD, GSH, MDA
Supervisor: Đikić, Domagoj
Date: 2014
Number of Pages: 47
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 17 Nov 2014 11:09
Last Modified: 17 Nov 2014 11:09
URI: http://digre.pmf.unizg.hr/id/eprint/3283

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata