The impact of microbes on tumor therapies

Čulo, Anja (2014) The impact of microbes on tumor therapies. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Human body is home to 10 14 microbes i 10 15 viruses. Microbes colonize all of the surfaces of the body that are exposed to the environment. It is important for human health to maintain constant composition of microbial populations. Long coevolution has led to complex interactions between human immune system and symbiotic microbes. In the absence of certain species of microbes, immune system will not develop normally. Some tumor therapies stimulate our immune system. Inflammatory responses play decisive roles at different stages of tumor development and reactions to therapy. Recent studies on mice showed that gut microbes affect few types of antitumor therapies which are often used in human treatment: CpG-oligonucleotide immunotherapy and platinum, cyclophosphamide and campothecin chemotherapy. Cancer patients usually get antibiotics after therapy to prevent possible infections due to weakened immune system. The use of antibiotics reduces the number of certain bacteria which results in decreased therapy efficiency. These findings could have major impact on tumor therapies in the future.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Ivančić Baće, Ivana
Date: 2014
Number of Pages: 16
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 18 Nov 2014 12:31
Last Modified: 18 Nov 2014 12:31
URI: http://digre.pmf.unizg.hr/id/eprint/3300

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