The role of DNA methylation during embryonic development of animals

Ivanković, Nina (2014) The role of DNA methylation during embryonic development of animals. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

DNA methylation is carried out by DNA methyltransferases 1, 3a and 3b. Dnmt1 ensures that DNA methylation pattern is maintained after each cell division. Dnmt3a and Dnmt3b are responsible for establishment of new DNA methylation pattern by their de novo methytransferase activity. Dnmt 1, 3a and 3b are known to be essential during embryonic development because targeted deletion of any one of them leads to developmental arrest at early stages of development and because mutations in Dnmt or proteins that cooperate with Dnmt impair normal development leading to severe disorders. DNA methylation changes the chromatin structure and with it changes the accessibility of DNA which leads to gene silencing or activation of gene expression, showed by the example of imprinted genes. Changes mentioned above, caused by DNA methylation, are known to be involved in cellular differentiation, formation of genomic imprinting in germ cells, expression of imprinted genes in cells on different differentiation levels, X chromosome inactivation and silencing of mobile genetic elements.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Lacković Venturin, Gordana
Date: 2014
Number of Pages: 12
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 19 Nov 2014 09:30
Last Modified: 16 Feb 2016 14:02
URI: http://digre.pmf.unizg.hr/id/eprint/3310

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