The impact of disrupted monoamine homeostasis on lipid metabolism, activity of monoamine oxidase type b and serotonin concentration in platelets

Puljić, Antonia (2014) The impact of disrupted monoamine homeostasis on lipid metabolism, activity of monoamine oxidase type b and serotonin concentration in platelets. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

The disruption of central monoamine homeostasis, as the basis of personality disorders and suicidal behaviour, affects lipid metabolism and monoamine oxidase type B (MAO-B) activity and serotonin (5-HT) concentration in platelets. Aim was to determine the influence of this altered homeostasis on lipid and platelet markers in female personality disorder patients with and without suicidal behaviour and to compare these markers with values in healthy control women. Methods: Lipid fractions and platelet markers were determined in blood samples of subjects with standard laboratory and spectrofluorimetric methods. Results were evaluated with analysis of variance, Tukey test, Student t-test, regression analysis and Spearman coefficient of correlation. Results: Serum total cholesterol was significantly lower in suicidal patients compared to control subjects, concentration of platelet 5-HT and LDL-cholesterol was significantly lower in suicidal and nonsuicidal patients compared to controls, and concentration of triglycerides was significantly higher in nonsuicidal patients compared to controls. Platelet 5-HT was significantly positively correlated with cholesterol and LDL-cholesterol. Conclusion: The concentration of platelet 5-HT and LDL cholesterol could serve as indicators of personality disorders, while serum total cholesterol, which is the only peripheral indicator that distinguishes suicidal and nonsuicidal patients, could serve as a potential indicator of suicididality. The results suggest that the reduced peripheral monoamine function, associated with cholesterol, is a characteristic feature of personality disorders.

Item Type: Thesis (Doctoral thesis)
Keywords: central monoamines, disrupted homeostasis, triglycerides, cholesterol, LDL- cholesterol, HDL- cholesterol, platelet serotonin, platelet monoamine oxidase, suicidality, personality disorder
Supervisor: Marčinko, Darko
Co-supervisor: Pivac, Nela
Date: 2014
Number of Pages: 128
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 19 Nov 2014 10:03
Last Modified: 19 Nov 2014 10:03
URI: http://digre.pmf.unizg.hr/id/eprint/3311

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