Viral Pandora's box – what can we learn from the largest viruses?

Kraus, Gloria (2014) Viral Pandora's box – what can we learn from the largest viruses?. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The discovery of the Pandoraviruses has shaken up the postulates of the viral world. The name “Pandoravirus” describes a lack of similarity with the existing microbes and surprises one might expect from the further research. With the 2.5 Mb genome and 2556 protein-coding sequences, they break all the records in the world of viruses. Although they are viruses by nature, they possess some components of the translational machinery as well as a handful of proteins which are homologous to bacterial, archaeal and eukaryotic proteins. Such characteristics exhibit evolutionary advantage over other existing viruses. However, the majority of Pandoravirus genome remains a mystery because it does not show any similarity with the genomes of the existing organisms. The analysis of B family DNA polymerases showed that Pandoraviruses, and other gigantic viruses, are phylogenetically different from the other organisms and they cluster together to form a fourth domain of life. Additional research is necessary to establish whether Pandoraviruses are really the missing link between the viral and the “living” world.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Škorić, Dijana
Date: 2014
Number of Pages: 14
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 19 Nov 2014 12:02
Last Modified: 19 Nov 2014 12:02
URI: http://digre.pmf.unizg.hr/id/eprint/3319

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