Discovery of a new type of mobile genetic elements

Papa, Lucija (2014) Discovery of a new type of mobile genetic elements. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Mobile genetic elements are defined DNA sequences capable of integrating into a host genome and moving from one location in the genome to the other. They are abundant in all three domains of life. Since they can render genes inactive by insertion inside the coding sequence, or bring novel genes to the host cell, mobile genetic elements are considered to be one of the main drivers of evolution. Casposons are recently discovered type of self-synthesizing prokaryotic mobile genetic elements. Although they share a number of traits with different types of prokaryotic and eukaryotic mobile genetic elements, they are the only ones to use Cas1 endonucleases for excision and integration into the host genome. Phylogenetic analysis was used to explore genetic relationships between casposons and other mobile genetic elements. Based on Cas1 protein phylogeny, it is proposed that Cas1 proteins from CRISPR-Cas adaptive immunity system in prokaryotes emerged from casposon Cas1 proteins. This suggests that casposons played a key role in the origin of acquired immunity in archaea and bacteria.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Ivančić Baće, Ivana
Date: 2014
Number of Pages: 18
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 20 Nov 2014 11:12
Last Modified: 20 Nov 2014 11:12
URI: http://digre.pmf.unizg.hr/id/eprint/3329

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