The role of telomeric sequence in ageing and human diseases

Prepeluh, Ivan (2014) The role of telomeric sequence in ageing and human diseases. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The ends of human and eukaryotic chromosomes terminate with telomeres, which play the key role in preserving the stability of the entire genome. Eukaryotic chromosomes are linear structures and during replication of their telomeras in each mitotic division, a part of their telomeric sequence is lost. When telomere length reaches a critical point (Hayflick limit), the cell no longer divides and enteres the phase of ageing (senescence) or enteres the process of cell death (apoptosis). Shortening of telomeres protects the cell from a malignant phenotype, reducing potential for cells to divide, however, with length loss, temorese lose their function and that can lead to the malignant phenotype. Malignant cells have eternal replication potential thanks to the telomerase enzyme that serves as a template for extending the chain of G-rich nucleotides. Telomeric area does not contain genes, but its disappearence leads to destruction of subtelomeric area which contains many genes. Because of damage in DNA of subtelomeric region there are many variety of mutations in genes that can occur and lead to various diseases and abnormal phenotypes.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Zoldoš, Vlatka
Date: 2014
Number of Pages: 9
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 20 Nov 2014 13:15
Last Modified: 20 Nov 2014 13:15
URI: http://digre.pmf.unizg.hr/id/eprint/3333

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