Programmable bacteria which can detect enviromental signals

Vujnović, Nebojša (2014) Programmable bacteria which can detect enviromental signals. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

In this seminar, construction methods and working principles of bacteria which can detect and record environmental signals in the mammalian gut are explained. The ability of engineered bacteria to report on enviromental cues in variable and incompletely understood environment has implications for development of new ways of diagnostics. For example, bacteria native to the human gut or skin might be used to monitor exposure to chemicals characteristic of specific disease state. The system described here is sufficiently modular that the trigger and memory circuits could be reengineered to respond to chemical signatures of inflammation, cancer, parasites, or presence of toxins in the gut. In combination with additional genetic circuits, such as the recent search-and-destroy circuits, bacteria could be designed with the memory element that can diagnose a specific pathogen and emit a therapeutic. Together these approaches may allow construction of a new class of engineered probiotic bacteria that could have wide diagnostic and therapeutic application.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Ivančić Baće, Ivana
Date: 2014
Number of Pages: 13
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 21 Nov 2014 11:40
Last Modified: 25 Aug 2017 08:37
URI: http://digre.pmf.unizg.hr/id/eprint/3342

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