Catalytic Antibodies

Žužić, Lorena (2014) Catalytic Antibodies. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Catalytic antibodies or abzymes are immunoglobulins with intrinsic catalytic properties. In order to obtain such antibodies, haptens which resemble the transition state of a given reaction are used as immunogens. Catalytic antibodies can be generated for a wide spectrum of chemical transformations – they include catalysts which show great level of stereoselectivity, those which utilize unusual cofactors, as well as antibodies that are able to catalyze reactions for which natural enzymes have yet to be found. Applications of antibody catalysis in biochemistry, organic chemistry, biotechnology and medicine are numerous, however, high costs, slow production and modest catalytic efficiency pose great limitations in further advancement of this technology. New perspective for catalytic antibodies arises from the field of medicine as they are being used as therapeutics in detoxification and cancer treatment.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Gruić Sovulj, Ita
Date: 2014
Number of Pages: 17
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 21 Nov 2014 11:50
Last Modified: 21 Nov 2014 11:50
URI: http://digre.pmf.unizg.hr/id/eprint/3343

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