Embryonic stem cells: possible role in disease treatment

Žužić, Marta (2014) Embryonic stem cells: possible role in disease treatment. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Embryonic stem cells are derived from the inner cell mass of a blastocyst, an earlystage preimplantation embryo. They are pluripotent, which means that they are able to differentiate into more than 200 cell types in the adult body. Additionally, under defined conditions, embryonic stem cells are capable of propagating themselves indefinitely. Because of ther plasticity and unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. Scientist successfully derived oligodendrocyte progenitors from human embryonic stem cells that could be used in treating spinal cord injuries, dopamin producing neurons for Parkinson's disease, astrocytes and motor neurons for amiotrophic lateral disease and retinal pigment epithelium for patients with Stargard't macular distrophy. These examples show how important research on embryonic stem cells really are. Besides the ethical concerns of stem cell therapy, there are some techical problems of graft-versus-host disease and forming teratomas. However, ethical problems and graft-versus-host disease can be solved using therapeutic cloning. Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as „in vitro“ systems for toxicology testing.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Lacković Venturin, Gordana
Date: 2014
Number of Pages: 22
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 25 Nov 2014 13:22
Last Modified: 16 Feb 2016 14:02
URI: http://digre.pmf.unizg.hr/id/eprint/3375

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