Biology of human papillomaviruses

Cindrić, Anita (2009) Biology of human papillomaviruses. Bachelor's thesis, Faculty of Science > Department of Biology.

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Human papillomaviruses (HPV) are small DNA viruses that infect human skin and mucosal keratinocytes and can couse warts. Specific HPV types have a role in the development of the cervical carcinoma. In seventies, with the development of the molecular biology techniques, active research of their molecular biology has begun. Today, the life cycle of these viruses, as well as their role in malignant transformation is well known. The HPV life cycle is intimately linked to the differentiation programme of their target, epithelial tissue. Viruses infect the basal cells of the epithelium. Specific viral proteins interact with cellular targets in order to postpone the differentiation and induce suprabasal proliferation. During the productive cycle, in the upper layers of the epithelium, viral DNA and capsid proteins are produced and packed in infective virions, as well as shed together with dead cornified skin layer. In certain number of so called high-risk HPV infections, viral DNA is integrated into the host genome. As a consequence, the production of the main viral regulator, E2 protein is abrogated, and viral oncogenes, E6 and E7 are produced. These proceses lead to uncontrolled cell proliferation, immortalization and genomic instability and contribute to neoplastic progression. HPV are considered today to be the main aetiological factor for cervical cancer. Basic research of its biology and interactions with cellular proceses contributed to the development of HPV vaccine which could prevene a majority of cervical cancers.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Matulić, Maja
Date: 2009
Number of Pages: 17
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 05 Dec 2014 11:53
Last Modified: 05 Dec 2014 11:53

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