Telomere length and immunoreactivity in posttraumatic stress disorder

Jergović, Mladen (2014) Telomere length and immunoreactivity in posttraumatic stress disorder. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

There is increasing evidence that chronic stress accelerates telomere erosion in leukocytes/ peripheral blood mononuclear cells (PBMCs). However, functional changes associated with telomere shortening are poorly understood. We measured relative telomere length and basal telomerase activity in PBMCs of 62 individuals (patients with posttraumatic stress disorder (PTSD) (N=30); age-matched healthy controls (N=17), elderly volunteers (N=15)). In parallel, we have assessed proliferation of activated T cells, interferon (IFN)-γ, interleukin (IL)-2, IL-4, tumor necrosis factor (TNF)-α and IL-6 cytokine production and expression of programmed death 1 (PD-1) receptor and its ligand PD-L1 on activated T cells. This study adds to the accumulating evidence that psychological trauma and chronic stress are associated with accelerated telomere attrition. Although much less pronounced in PTSD patients than in elderly persons, reduced proliferative responses of T cells accompanied by shorter telomeres might be a sign of early immunosenescence. Together with reduced production of Th1 cytokines, observed immune changes may contribute to health risks associated with PTSD.

Item Type: Thesis (Doctoral thesis)
Keywords: telomeres, posttraumatic stress disorder, immunity, immunosenescence
Supervisor: Bendelja, Krešo and Vidović, Anđelko
Date: 2014
Number of Pages: 57
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 10 Dec 2014 10:22
Last Modified: 10 Dec 2014 10:22
URI: http://digre.pmf.unizg.hr/id/eprint/3490

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