The role of FADD protein in cell death

Antunović, Maja (2014) The role of FADD protein in cell death. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Based on the presumption that FADD protein (Fas-Associated protein with Death Domain) intermediates apoptotic, necroptotic and autophagic signals after exposure to NB-UVB (Narrowband Ultraviolet B) irradiation, we tested its role of death adaptor using FADD knockout mouse embrionic fibroblasts. The results show that wild type mouse embryonic fibroblast die by triggering apoptotic death signals through mitochondrial control, but independently of p53. FADD knockout mouse embrionic fibroblasts die by programmed necrosis and autophagy, by activating caspase-3 and -9. Their necrotic programme does not involve p53 nor Bax and Bcl-2. The results show that protein FADD, as well as RIPK1 (Receptor-interacting serine/threonine-protein kinase 1), are essential for triggering apoptotic cell death mechanism. FADD protein is not necessary for autophagic mechanism followed by necroptosis after NB-UVB irradiation.

Item Type: Thesis (Doctoral thesis)
Keywords: FADD protein, apoptosis, necroptosis, autophagy, programmed cell death
Supervisor: Marijanović, Inga
Date: 2014
Number of Pages: 118
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 10 Dec 2014 11:08
Last Modified: 10 Dec 2014 11:08
URI: http://digre.pmf.unizg.hr/id/eprint/3491

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