Effect of induced hematopoiesis on osteoclast differentiation and activity in mice

Kuzmac, Sania (2014) Effect of induced hematopoiesis on osteoclast differentiation and activity in mice. Doctoral thesis, Faculty of Science > Department of Biology.

Full text not available from this repository. (Request a copy)

Abstract

Osteoclasts are components of hematopoietic bone marrow niche, but their role as hematopoietic contributors are still controversial. We aimed to investigate whether an acute and chronic blood loss and the consequent intense hematopoiesis would affect osteoclast differentiation and activity in mice. In the model of acute blood loss research was focused on specific subpopulations of osteoclast precursors, expression of osteoclastogenesis- and osteoblastogenesis-related genes and the potential of bone marrow cells to form osteoclast-like cells in vitro, while in the model of chronic blood loss on bone cells activity in vivo. There were no significant changes of cells with high osteoclastogenic potential, but we observed promoted osteoclast maturation following acute blood loss. Chronic blood loss had no effect on osteoclast activity and remodeling of trabecular bone. Our data demonstrate that blood loss does not promote osteoclast activity and osteoresorption to provide additional space for bone marrow.

Item Type: Thesis (Doctoral thesis)
Keywords: bleeding, bone, bone marrow, hematopoiesis, osteoblasts, osteoclasts
Supervisor: Katavić, Vedran
Date: 2014
Number of Pages: 109
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 10 Dec 2014 11:14
Last Modified: 10 Dec 2014 11:14
URI: http://digre.pmf.unizg.hr/id/eprint/3492

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata