Flavonoid metabolism

Radić, Marija (2009) Flavonoid metabolism. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Flavonoids are a major group of phenolic compounds which are important in flavouring and colouring of many fruits and vegetables and derived products such as wine, tea preparations and chocolate. They are structurally diverse and among the most ubiquitous groups of dietary polyphenols. Dietary polyphenols are a main source of antioxidants for humans. Recently, flavonoids are given much attention due to their excellent antioxidative and antiradical activity. These polyphenols have a variety of biological activities, ranging from antiaging and anticancer to lowering of blood cholesterol levels and improving bone strength. Flavonoids also have other biochemical activities; some have been found to possess significant anti-cardiovascular disease activity, anti-inflammatory, antiviral, and anti-tumour activities. It is important to realize that the polyphenols that are the most common in the human diet are not necessarily the most active within the body, either because they have a lower intrinsic activity or because they are poorly absorbed from the intestine, highly metabolized (flavonoids undergo metabolic transformation such as methylation, sulfation and glucuronidation), or rapidly eliminated. In addition, the metabolites that are found in blood and target organs and that result from digestive or hepatic activity may differ from the native substances in terms of biological activity. Extensive knowledge of the bioavailability of polyphenols is thus essential if their health effects are to be understood. In order to reveal a relationship between parent compounds and their metabolites, the changes of structure and bioactivity of various flavonoids are reviewed in the vitro and vivo models.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Rusak, Gordana
Date: 2009
Number of Pages: 9
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 15 Dec 2014 09:59
Last Modified: 15 Dec 2014 09:59
URI: http://digre.pmf.unizg.hr/id/eprint/3520

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