The use of bacteria as vectors in tumour treatment

Remenarić, Mateja (2009) The use of bacteria as vectors in tumour treatment. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

Tumour is one of the most common and the most widely spread cause of death in humans in the modern world. Scientists became more interested in finding a more effective tumour treatment than those commonly used, such as radio- and chemotherapy, with the increase in the number of tumour patients. Although the beneficial effect of some bacterial infections on tumour regression was observed a few centuries ago, the interest in bacteria arose once again with the development of genetic engineering, which led to the use of bacteria as vectors for targeted tumour treatment. Most researches were performed on three genera of bacteria: Bifidobacterium, Salmonella and Clostridium, which are presented in this work. All of these genera have their advantages and disadvantages but the most promising seems to be Clostridium because they are strictly anaerobic, spore forming bacteria with a great capacity to colonize tumours. Bacteria were engineered to express prodrug activating enzyme inside the tumour, thus lowering systemic toxicity induced by the activated prodrug. Engineered bacteria have been shown to serve as a more efficient and safer vector for tumour treatment then the viral vectors. Although bacterial vectors have been shown to be successful in many tumour models, further experiments and researches are necessary for completing all clinical trials and entering a wide use in treating tumour patients. However, bacterial vectors could be a turning point in tumour treatment as well as for other diseases unreachable to conventional therapies.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Ivančić Baće, Ivana
Date: 2009
Number of Pages: 11
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 16 Dec 2014 13:43
Last Modified: 16 Dec 2014 13:43
URI: http://digre.pmf.unizg.hr/id/eprint/3528

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