Topology of nucleosomes in chromatin structure

Vučković, Frano (2009) Topology of nucleosomes in chromatin structure. Bachelor's thesis, Faculty of Science > Department of Biology.

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DNA in eukaryotic chromosomes is organized in the nucleosomes, structures which contain proteins and DNA, and which represent elementary structural and functional unit of chromosomal material, chromatin. Arrays of nucleosomes are folded into higher order structure, 30 nm chromatin fiber. Although the structure of nucleosome is known in smallest detail, only a few facts are known about 30 nm fibre and higher chromatin structures. In this work, I exposed models for structure of 30 nm chromatin fibers: solenoid, twisted-ribbon, two-started crossed-linker and one-started nonsequential model, with difference in the path of DNA between two nucleosomes. Uncovering of 30 nm fibre structure is crucial for understanding the regulation of processes such as transcription, recombination, DNA repair and replication.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Besendorfer, Višnja
Date: 2009
Number of Pages: 15
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 19 Dec 2014 10:49
Last Modified: 19 Dec 2014 10:49

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