Cyclin-dependent kinase inhibitors

Jemin, Nikolina (2009) Cyclin-dependent kinase inhibitors. Bachelor's thesis, Faculty of Science > Department of Biology.

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Abstract

The cell cycle is one of the most important processes in the cell. It enables the transfer of identical genetic material between generations and assures its complete preservation. The cycle is regulated by multiple signals and corresponding signaling pathways. Defect or lack of the cell cycle regulators could lead to uncontrolled proliferation and genome damage, resulting in carcinogenic processes. In this paper the basics of the cell cycle is presented, as well as the mechanisms that regulates it. The main topic is the cell proliferation inhibition and specific protein cyclin dependent kinase inhibitors. It shows structure, function and mechanical role of each of the cyclin dependent kinases inhibitors, as well as their effectors pathway. DNA damage, mutation or epigenetic alteration could lead to loss of CDKI functions and could have catastrophic consequences on the cell and the entire organism. CDK inhibitors are also involved in a number of other cell mechanisms. p21 and p16 are the main factors of the irreversible cell cycle arrest in senescence. CDKI are an important cell defense response in the fight against damage caused by various chemical and physical agents, or spontaneous arisen in the cell, as well as a defense mechanism against procarcinogenic effects of shortened and damaged telomeres.

Item Type: Thesis (Bachelor's thesis)
Supervisor: Matulić, Maja
Date: 2009
Number of Pages: 17
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 22 Dec 2014 12:36
Last Modified: 22 Dec 2014 12:36
URI: http://digre.pmf.unizg.hr/id/eprint/3579

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