Reduction of ribonucleotide in prebiotic conditions

Dragičević, Ivan (2014) Reduction of ribonucleotide in prebiotic conditions. Doctoral thesis, Faculty of Science > Department of Chemistry.

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The origin of life on Earth is one of the biggest unanswered questions in science. The prerequisite for creation of the first living organisms was the existence of a "molecules of life" such as nucleic acids, amino acids and sugars. Reconstruction of the processes that have led to the formation of these molecules in prebiotic phase is an interesting problem in modern chemistry. In this thesis, using the computational chemistry approach, different mechanisms of non-enzymatic reduction of ribonucleotide to deoxyribonucleotide, a precursor of DNA, were investigated. Nowadays, the deoxyribonucleotides are formed in enzymatically catalyzed reduction of ribonucleotides by ribonucleotide reductases (RNR). Using the G3(MP2)-RAD method and density functional theory (DFT) methods several mechanisms of ribonucleotide reduction were modeled in giving an answer about the possibilities of regioselective radical reduction of ribonucleotide without the presence of enzymes.

Item Type: Thesis (Doctoral thesis)
Keywords: riobnucleotide, reduction, G3(MP2)-RAD, prebiotic conditions, density functional theory, computational chemistry
Supervisor: Barić, Danijela
Date: 2014
Number of Pages: 123
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: mag. bibl. Ana Šafran
Date Deposited: 30 Jan 2015 09:53
Last Modified: 14 Oct 2015 08:03

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