Kinesin-8 Motors Improve Nuclear Centering by Promoting Microtubule Catastrophe

Glunčić, Matko and Maghelli, Nicola and Krull, Alexander and Krstić, Vladimir and Ramunno-Johnson, Damien and Pavin, Nenad and Tolić, Iva Marija (2015) Kinesin-8 Motors Improve Nuclear Centering by Promoting Microtubule Catastrophe. Physical Review Letters, 114 (7). pp. 78103-5. ISSN 0031-9007

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Abstract

In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers.

Item Type: Article
Date: 18 February 2015
Subjects: NATURAL SCIENCES > Physics
Additional Information: Copyright (2015) by the American Physical Society.
Divisions: Faculty of Science > Department of Physics
Publisher: American Physical Society
Depositing User: Gordana Stubičan Ladešić
Date Deposited: 26 Feb 2015 12:29
Last Modified: 26 Feb 2015 12:29
URI: http://digre.pmf.unizg.hr/id/eprint/3710

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