Correlation of the polymorphisms in the mitochondrial DNA with the biological indicators of aging and bone mineral density

Anterić, Ivana (2015) Correlation of the polymorphisms in the mitochondrial DNA with the biological indicators of aging and bone mineral density. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

To better understand the dynamic of aging, biological indicators of aging: telomeres, glycan index of aging and bone mineral density, are used. The aim of this research was to analyse the correlation of mtDNA with the biological indicators of aging. The study was conducted on sample of 872 people from the island of Korčula. Genotyping was conducted by the analysis of the vein blood using microarray Ilumina CNV370; telomere length was measured from the amplified DNA using PCR which enabled determination of relative ratios of repeating number of telomeres with the copy of one gene and compared with referent sample; glycan analysis was conducted using high-performance liquid chromatography based on hydrophilic interactions; mineral bone density was determined using calcaneus densitometry (dual energy X – ray absorptiometry). Statistically significant difference was found among mtDNA haplogroups and mineral bone density, no correlation was found between mtDNA haplogropus and shortening of telomers, that is N-glycane profile, as well as the connection of SNPs with the biological indicators of aging.

Item Type: Thesis (Doctoral thesis)
Keywords: the island of Korcula, mtDNA, glycan index of aging, telomeres, bone mineral density
Supervisor: Polašek, Ozren and Gornik, Olga
Date: 2015
Number of Pages: 88
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 04 Mar 2015 09:38
Last Modified: 04 Mar 2015 09:38
URI: http://digre.pmf.unizg.hr/id/eprint/3715

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