Role of hypoxia in the development of triple negative invasive ductal breast carcinoma

Alvir, Ilija (2015) Role of hypoxia in the development of triple negative invasive ductal breast carcinoma. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Breast cancer (BC) is the most common type of cancer in women. Numerous tumor indicators are used to monitor BC: size, multicentricity, histological type and grade, status of estrogen and progesterone receptors (ER and PR), HER2 status, lymphovascular invasion, positive axillary lymph nodes and presence of distant metastases. The triple negative breast cancer (triple negative breast cancer, TNBC) is very aggressive subtype of BC with a high rate of recurrence and poor survival. Tumor hypoxia is an important indicator of malignant disease prognosis, associated with aggressive growth, early metastasis and poor response to treatment. In hypoxic conditions an increased expression of p53 occurs along with induction of apoptosis via Bcl-2. Using immunohistochemical methods, we investigated the correlation of expression of cellular hypoxia markers, carbonic anhydrase IX (CAIX), Bcl-2, p53 and Ki-67 with indicators of cancer aggressiveness. The results indicated that investigated hypoxia marker CAIX is in statistically significant positive correlation with both p53 and Ki-67. Only p53 was correlated with any of investigated marker. Apoptotic marker Bcl-2 is more expressed at larger tumors. This study confirmed that TNBC have aggressive behavior from the very beginning. Since the vast majority of TNBC expressed markers of hypoxia maybe some of these markers have potential for development targeted therapies.

Item Type: Thesis (Doctoral thesis)
Keywords: braest cancer, carboanhydrase IX, p53, Bcl-2, Ki-67
Supervisor: Beketić-Orešković, Lidija
Date: 2015
Number of Pages: 73
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 04 Mar 2015 09:49
Last Modified: 04 Mar 2015 09:49
URI: http://digre.pmf.unizg.hr/id/eprint/3717

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