Polymorphism of FSH receptor gene in Albanian women

Gashi, Zafer (2015) Polymorphism of FSH receptor gene in Albanian women. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

This study investigated association of Asn680Ser FSHR polymorphism with the ovarian response in 104 women of Albanian ethnic population enrolled in ICSI program. The reason of infertility in all cases has been identified as male factor. Analysis of the Asn680Ser polymorphism was performed using TaqManR SNP Genotyping Assay. The frequencies of genotypes were: Asn/Asn 22.1%, Asn/Ser 47.1%, and Ser/Ser 30.8%. Clinical and endocrinologic parameters were analyzed based on the genotype, age, BMI and oocyte yield. BMI was significantly higher in the Ser/Ser as compared to the Asn/Ser (P= 0.0152) or the Asn/Asn group (P= 0.0014). Except significantly (P= 0.0404) higher prolactin levels in the overweight (BMI ≥ 25) group, no other statistically relevant differences were found between the two BMI subgroups. Basic E2 levels showed statistically significant difference (0.0308) between the genotype variants. Statistically significant differences between poor and good responders were found regarding the age, BMI, bFSH, AFC, gonadotropin dose, stimulation length, embryo transfer number and number of dominant follicle, peak E2 levels and endometrium thickness. Correlation analysis showed statistically significant (P< 0.0001) negative correlation of oocyte retrieval number in respect to age, bFSH, stimulation length and gonadotropin dose. AFC and embryo transfer number, as well as number of dominant follicle, peak E2 level and endometrium thickness have all showed statistically significant (P< 0.0001) positive correlation with oocyte yield.

Item Type: Thesis (Doctoral thesis)
Keywords: FSHR, SNP, polymorphism, infertility, controlled ovarian stimulation
Supervisor: Vujisić Živković, Sanja
Date: 2015
Number of Pages: 92
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 04 Mar 2015 10:21
Last Modified: 04 Mar 2015 10:21
URI: http://digre.pmf.unizg.hr/id/eprint/3719

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