The role of CD4+FOXP3+ I CD4+TH17+ lymphocytes in borderline acute cellular rejection of renal allografts

Bacalja, Jasna (2015) The role of CD4+FOXP3+ I CD4+TH17+ lymphocytes in borderline acute cellular rejection of renal allografts. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Borderline acute cellular rejection of renal allograft (borderline ACR) is considered when histological changes in renal allograft tissue are suspicious for rejection, but do not have enough criteria for making a diagnosis of acute cellular rejection. We wanted to define if CD4+Foxp3+ and CD4+Th17+ lymphocytes in renal allograft tissue with borderline ACR can determine if the reaction is indeed acute rejection or is it just physiological conditioning of the body to new organ. Also, we wanted to explore if these lymphocytes are involved in arising of acute and chronic changes in renal allograft. Based on the results we concluded that CD4+Th17+ lymphocytes increase acute changes and probably have a role in their evolving while the number of CD4+Foxp3+ lymphocytes does not correlate with rejection in borderline ACR, but the number of CD4+Th17+ lymphocytes in renal allograft tissue with borderline ACR can determine if the reaction is indeed acute rejection.

Item Type: Thesis (Doctoral thesis)
Keywords: renal allograft, Borderline acute cellular rejection, CD4+ lymphocytes, Foxp3+ lymphocytes, IL-17+ lymphocytes
Supervisor: Galešić Ljubanović, Danica
Date: 2015
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 10 Apr 2015 10:15
Last Modified: 10 Apr 2015 10:15
URI: http://digre.pmf.unizg.hr/id/eprint/3802

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