pproteomic analysis of human breast cancer cells MDA-MB-435S after silencing integrin αv

Kovačević, Alen (2015) pproteomic analysis of human breast cancer cells MDA-MB-435S after silencing integrin αv. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Integrins are transmembrane glycoproteins that mediate cell-cell and cell-ECM interactions. They are a part of signal transduction pathways that regulate numerous cell processes such as cell adhesion, growth, proliferation, differentiation and migration. Human breast carcinoma cell line MDA-MB-435S expresses integrins αVβ3 and αVβ5. The silencing of integrins αvβ3 and αvβ5, achieved by αv-specific siRNA transfection, increases sensitivity of MDA-MB-435S cells to vincristine and paclitaxel and reduces their migratory potential. In this study we describe changes in MDA-MB-435S proteome profile upon integrin αV silencing. These results could contribute to better understanding of molecular mechanisms involved in MDA-MB- 435S chemosensitation as well as mechanisms involved in decreased cell migration after integin αV silencing.

Item Type: Thesis (Diploma thesis)
Keywords: breast cancer, MDA-MB-435S, anti-cancer drugs, integrins, proteomics
Supervisor: Cindrić, Mario and Ambriović Ristov, Andreja
Date: 2015
Number of Pages: 62
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 22 Apr 2015 11:13
Last Modified: 22 Apr 2015 11:13
URI: http://digre.pmf.unizg.hr/id/eprint/3859

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