Alarmin network and total gene expression in juvenile systemic lupus erythematosus

Lukić, Anita (2013) Alarmin network and total gene expression in juvenile systemic lupus erythematosus. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

In this study, we investigated concentration and gene expression of alarmins S100A12, HMGB1, and their receptor RAGE in children with juvenile systemic lupus erythematosus (JSLE), as well as total gene expression of children with JSLE from GEO base study No. GSE11909. The concentrations of S100A12, HMGB1 and RAGE in children with JSLE were comparable to those in healthy children, while children with JSLE had lower expression of genes for S100A12, and higher expression of genes for HMGB1 and RAGE compared to healthy children. In the GEO base study No. GSE11909 children with JSLE had higher expression for 2172 significant genes that mostly enriched four functional groups: interferon 1 pathway genes, interferon γ pathway genes, cytokine signalization genes, and caspase activation genes. The fact that significant genes enriched functional groups encoding interferon pathway members indicates involvement of innate immunity genes in pathophysiology of JSLE, and higher expression of genes involved in activation of caspases in children with JSLE could contribute to the development of JSLE.

Item Type: Thesis (Doctoral thesis)
Keywords: juvenile systemic lupus erythematosus, alarmins, HMGB1, S100A12, RAGE, total gene expression
Supervisor: Jelušić-Dražić, Marija
Date: 2013
Number of Pages: 119
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 10 Feb 2014 11:48
Last Modified: 22 Sep 2014 12:14
URI: http://digre.pmf.unizg.hr/id/eprint/389

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