Antioxdidative activity of naringenin in diabetic mice

Ugrinić, Martina (2014) Antioxdidative activity of naringenin in diabetic mice. Diploma thesis, Faculty of Science > Department of Biology.

[img] PDF
Restricted to Registered users only
Language: Croatian

Download (4MB) | Request a copy

Abstract

The present study was designed to investigate the possible antidiabetic and protective effect of naringenin against alloxan-induced oxidative damage in diabetic mice. Type 1 diabetes was induced with alloxan in dose of 75 mg kg-1 btw iv. After 2 days appears to increase glucose levels in alloxan treated animals, and 10th days of the initiation of alloxan show significant decrease of body weight compared to a healthy control group. Treatment of diabetic mice with naringenin in dose of 50 mg kg-1 for seven days reduced the decline in body mass, reduced histopathologycal changes of liver and kidney, increased functional activity of macrophages peritoneal cavity and increases the survival of mice. Additionaly comet assay results show that treatment with naringenin reduces the alloxan-induced DNA damage to lymphocytes. The results indicate that naringenin has promising effects in reducing the negative consequences of developing diabetes, which contributes to its antioxidant potential.

Item Type: Thesis (Diploma thesis)
Keywords: diabetes, oxidative stress, alloxan, flavonoids, naringenin, mice
Supervisor: Oršolić, Nada
Date: 2014
Number of Pages: 48
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 13 May 2015 09:33
Last Modified: 13 May 2015 09:33
URI: http://digre.pmf.unizg.hr/id/eprint/3969

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata