Genetic, immunohistochemical and morphological features of subgroups in diffuse large B-cell lymphoma

Škunca, Željka (2013) Genetic, immunohistochemical and morphological features of subgroups in diffuse large B-cell lymphoma. Doctoral thesis, Faculty of Science > Department of Biology.

[img] PDF
Restricted to Registered users only
Language: Croatian

Download (1MB) | Request a copy

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in patient's elderly population. With such a high representation we decided our patients asses the pressence of VEGFR2 and NF-ĸB and assess their impact on outcome in patients with DLBCL. We investigated in 99 patients the presence of tumor markers and abnormalities of genes BCL2, BCL6 and c-MYC in the same group of patients. The results showed that in immunochistochemical markers of tumor VEGFR2 and NF-ĸB which are located in the cytoplasm and in the nucleus was found that only NF-ĸB, which is present in the cytoplasm indicates a singnificantly worse survival (p=0.037). FISH analaysis of BCL2, BCL6 and c-MYC was not found significant differences in survival among subgroups of DLBCL (p=0.714).

Item Type: Thesis (Doctoral thesis)
Keywords: diffuse large B-cell lymphoma, tumor markers,
Supervisor: Planinc-Peraica, Ana
Date: 2013
Number of Pages: 120
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 10 Feb 2014 14:31
Last Modified: 22 Sep 2014 20:05
URI: http://digre.pmf.unizg.hr/id/eprint/404

Actions (login required)

View Item View Item

Nema podataka za dohvacanje citata