The role of brain derived neurotrophic factor in development of coronary heart disease in obese patients

Šustar, Aleksandra (2015) The role of brain derived neurotrophic factor in development of coronary heart disease in obese patients. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Brain derived neurotrophic factor (BDNF) is a neurotrophin with important role in regulation of body weight and obesity. Obesity is a substantial risk factor for coronary heart disease (CHD). Aim was to determine the association between CHD, obesity and plasma BDNF concentration and BDNF Val66Met genotype frequency, and the influence of risk factors for development of CHD and obesity, in subjects with CHD and healthy control subjects. Plasma BDNF concentration was significantly lower in CHD patients than in control subjects, but did not differ between obese and non-obese subjects, or between different BDNF Val66Met genotype carriers. BDNF Val66Met genotype frequency was similar in subjects with or without CHD and/or obesity. Risk factors/indicators for CHD were concentrations of BDNF, glucose, HDL-cholesterol and waist circumference, and for obesity only waist circumference. The results suggest the role of BDNF in CHD and its potential application in the diagnosis of CHD, but not in obesity.

Item Type: Thesis (Doctoral thesis)
Keywords: brain derived neurotrophic factor (BDNF), BDNF Val66Met polymorphism, coronary heart disease, obesity, lipid fractions, risk factors
Supervisor: Pivac, Nela
Date: 2015
Number of Pages: 155
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 06 Jul 2015 09:25
Last Modified: 06 Jul 2015 09:25
URI: http://digre.pmf.unizg.hr/id/eprint/4091

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