Photophysical and photochemical properties of resveratrol and its reactions with biologically relevant free radicals

Džeba, Iva (2015) Photophysical and photochemical properties of resveratrol and its reactions with biologically relevant free radicals. Doctoral thesis, Faculty of Science > Department of Chemistry.

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Abstract

It is well known that natural compound trans-resveratrol (trans-3,5,4'-trihydroxystilbene) possesses significant biological activity. However, despite the knowledge of its possible antioxidant mechanisms which have a protective role in the living organisms, chemical properties of ArOH are less known. The main goal of this thesis is to investigate reaction kinetics and mechanisms of ArOH with so far unresearched free bioradicals which occur in the conditions of oxidative stress. These free radicals and ArOH excited states were generated with ruby or Nd:YAG laser flash or electron accelerator pulse. Short-lived intermediate species of ArOH and its reaction kinetics with oxygen, sulphur and carbon-centered radicals and aromatic carbonyl triplets were determined with transient absorption spectroscopy. Measurements were conducted at the 10‒6‒10‒12 sec time scales in acetonitrile and solutions of water/alcohol. This research is original contribution to the understanding of the mechanism and reaction kinetics of ArOH antioxidant activity with biologically relevant free radicals under investigation which are known to be responsible for the malfunction of the normal processes in living cells.

Item Type: Thesis (Doctoral thesis)
Keywords: antioxidant, free radicals, oxidative stress, rate constant, resveratrol, transient absorption spectroscopy
Supervisor: Mihaljević, Branka
Date: 2015
Number of Pages: 117
Subjects: NATURAL SCIENCES > Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Branka Maravic
Date Deposited: 10 Jul 2015 08:46
Last Modified: 10 Jul 2015 08:46
URI: http://digre.pmf.unizg.hr/id/eprint/4107

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