Višestruko poravnavanje i HMM

Stojković, Mihaela (2015) Višestruko poravnavanje i HMM. Diploma thesis, Faculty of Science > Department of Mathematics.

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Abstract

Multiple sequence alignment is an important object in bioinformatics for obtaining information about protein families. In this thesis we show how to build a multiple sequence alignment using hidden Markov models. We have observed that the results are very sensitive to the choice of various parameters and sample biased. Analysis carried out consists of model estimation from given alignment, simulation and realigning. Distribution of scores is approximately Gumbel, as expected. Since parametrisation of a family profile is a very sensitive procedure, we gradually build a model using less variable subsamples. This method provides a good solution to avoid some of the obstacles we encountered.

Item Type: Thesis (Diploma thesis)
Supervisor: Goldstein, Pavle
Date: 2015
Number of Pages: 32
Subjects: NATURAL SCIENCES > Mathematics
Divisions: Faculty of Science > Department of Mathematics
Depositing User: Iva Prah
Date Deposited: 27 Oct 2015 12:49
Last Modified: 27 Oct 2015 12:49
URI: http://digre.pmf.unizg.hr/id/eprint/4189

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