Statistika višestrukog poravnanja

Vragović, Mateja (2015) Statistika višestrukog poravnanja. Diploma thesis, Faculty of Science > Department of Mathematics.

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Abstract

In this thesis, we want to describe a protein family profile. To describe the family profile means to estimate the parameters of the Hidden Markov Model associated to an alignment. Family profile enables aligning of newly discovered family members with an already existing alignment. Estimation of the model parameters is not a simple procedure, some parameters are estimated, others are given. If we change a single value in the estimate, the resulting alignment might change, therefore, our estimate is not robust. From a given protein family we estimate the initial parameters, and we would like to get parameters so that the alignment of the family will be the most similar to original alignment. We repeated the estimation procedure twice and that yielded a better alignment. Although we have made only two model estimations, this procedure can, clearly, be iterated. However, we do not expect to obtain an alignment identical to the one we started with.

Item Type: Thesis (Diploma thesis)
Supervisor: Goldstein, Pavle
Date: 2015
Number of Pages: 31
Subjects: NATURAL SCIENCES > Mathematics
Divisions: Faculty of Science > Department of Mathematics
Depositing User: Iva Prah
Date Deposited: 29 Oct 2015 11:56
Last Modified: 29 Oct 2015 11:56
URI: http://digre.pmf.unizg.hr/id/eprint/4197

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