Association of adiponectin gene polymorphisms with blood pressure in persons with normal kidney function

Ivković, Vanja (2015) Association of adiponectin gene polymorphisms with blood pressure in persons with normal kidney function. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Adiponectin is a protein with antiatherogenous, antiinflammatory and antidiabetic effects. It was found in some studies that its plasma concentration is inversely associated with blood pressure. In this thesis we evaluated the association of two common adiponectin gene polymorphisms, -11377 C>G and -11391 G>A, with blood pressure in persons with normal kidney function. Normotensives and hypertensives did not differ in plasma adiponectin concentration and adiponectin concentration was not correlated with blood pressure in the whole group or in different subgroups. Adiponectin gene polymorphisms were not associated with blood pressure or hypertension, but polymorphism -11391 G>A was associated with insulin resistance, with minor alelle A carrying increased risk. In our group of subjects adiponectin gene polymorphisms were not associated with blood pressure but further larger epidemiologic studies are warranted to clarify this relationship completely.

Item Type: Thesis (Doctoral thesis)
Keywords: adiponectin, polymorphisms, hypertension, insulin resistance.
Supervisor: Jelaković, Bojan
Date: 2015
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 09 Oct 2015 10:24
Last Modified: 09 Oct 2015 10:24
URI: http://digre.pmf.unizg.hr/id/eprint/4266

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