Expression pattern of neurocan in fetal human neostriatum

Mavrović, Martina (2013) Expression pattern of neurocan in fetal human neostriatum. Diploma thesis, Faculty of Science > Department of Biology.

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The aim of this study is to evaluate the expression pattern at histological level of the chondroiotin-sulphate proteoglycan neurocan (NCAN) in the human fetal neostriatum from gestation weeks (GW) 12 to 40, using indirect immunohystochemical staining on postmortal brain tissue. Neurocan is expressed in the neostriatum from 16 – 25 GW. In the early phase of expression, from 16 – 18 GW, neurocan is expressed in the cell islands – striosomes, and at 19/20 GW shows a shift in expression from the striosomes to the surrounding matrix. After the 23rd GW neurocan expression declines untill GW 27 when its expression ceases. Neurocan shows the highest rate of expression between the 19th - 23 GW in a tight cell-free zone that surrounds the striosomes – the peristriosomes or perimeters, which are most pronounced during fetal and early postnatal development. We propose that the selective expression of neurocan in the different modules of the fetal striatum reflects the differences in the sequence of growth and maturation of striatal afferents, and/or that neurocan has a role in forming the boundaries between striatal modules.

Item Type: Thesis (Diploma thesis)
Keywords: fetal development, chondroiotin-sulphate proteoglycans, basal ganglia, striosomes
Supervisor: Jovanov-Milošević, Nataša
Co-supervisor: Hranilović, Dubravka
Date: 2013
Number of Pages: 29
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 19 Feb 2014 12:32
Last Modified: 22 Sep 2014 12:41

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