Analysis of VEGF polymorphisms in sporadic colon cancer

Ponoš, Josipa (2013) Analysis of VEGF polymorphisms in sporadic colon cancer. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Colon cancer arises from a stepwise accumulation of genetic and epigenetic changes in the number of oncogenes and tumor suppressor genes. Angiogenesis is necessary for the formation and progression of tumors, and vascular endothelial growth factor (VEGF) is one of its key mediators. Since the VEGF expression can be affected by regulatory SNP polymorphisms, objective of this study was to investigate the role of these polymorphisms in the susceptibility to and survival of patients with sporadic colorectal cancer. VEGF polymorphisms -634G/C and +936 C/T were genotyped using TaqManTM real-time PCR. No association was found between genotypes and haplotypes and susceptibility to sporadic colorectal cancer. Survival analysis showed that patients with established presence of VEGF -634 C allele lived longer (p=0.01), while the +936 C/T VEGF polymorphism had no influence on patients’ survival.

Item Type: Thesis (Diploma thesis)
Keywords: colon cancer, VEGF, -634G/C, +936C/T, real-time PCR
Supervisor: Čačev, Tamara
Co-supervisor: Matulić, Maja
Date: 2013
Number of Pages: 37
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 20 Feb 2014 13:15
Last Modified: 22 Sep 2014 19:21
URI: http://digre.pmf.unizg.hr/id/eprint/451

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