Mutations in core region of hepatitis C virus in patients with chronic hepatitis

Mohar Vitezić, Bojana (2016) Mutations in core region of hepatitis C virus in patients with chronic hepatitis. Doctoral thesis, Faculty of Science > Department of Biology.

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Abstract

Hepatitis C virus (HCV) is a globally prevalent pathogen with diverse clinical outcomes. Considering the interlinking relation of the host and the virus, the genetics of HCV and infection in humans is specific and individual . Thus, it can result in a variety of different disease course among the infected hepatitis C patients. HCV core is complex protein, capable of modifying hepatitis C life cycle by participating in interactions with host proteins, altering cellular signaling pathways and contributing in hepatocarcinogenesis. The aim of this study was to investigate correlations between the changes of core region and the viral and patohistological parameters of chronic hepatitis C in liver and serum samples of 87 patients. The aim was also to determine coherence of core region mutations and liver disease progression. Results of this study indicate significant correlation of genotype 1b and basal viremia with presence of R70Q, T75A i M91L/C mutations. Patohistological parameters (hepatitis activity grade and fibrosis stage) were associated with presence of R70Q and M91L/C mutations. Finally, results of our study indicate that frequency and the type of mutations positively correlates with liver disease progressivity.

Item Type: Thesis (Doctoral thesis)
Keywords: hepatitis C/core protein/sequencing/chronic hepatitis C/viral and patohistological parameters
Supervisor: Grahovac, Blaženka
Date: 2016
Number of Pages: 122
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 03 Mar 2016 14:15
Last Modified: 03 Mar 2016 14:15
URI: http://digre.pmf.unizg.hr/id/eprint/4533

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