The effects of vasodilators and anticoagulants on the oxidative stress levels of the rat brain

Krasić, Jure (2015) The effects of vasodilators and anticoagulants on the oxidative stress levels of the rat brain. Diploma thesis, Faculty of Science > Department of Biology.

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Previous toxicological research showed that blood brain barrier and brain vascular system are highly susceptible to the effects of pharmaceuticals with vasodilatation or anticoagulative properties. The adverse effects on cellular oxidative stress caused by over the counter (OTC) household drugs (acetylsalicylic acid), herbal remedies and pills (for example ginkgo) or prescription drugs (warfarin) are well described. Much less is known about mutual interaction between these substances on oxidative stress levels especially in the brain. Within this study Y59 rats were treated daily with corresponding recommended doses and combinations of acetylsalicylic acid, ginkgo and warfarine during 15 days. Four markers of oxidative stress were assessed; superoxide dismutase (SOD), catalase (CAT), gluthathione (GSH) and malondialdehyde (MDA) in various brain regions. The results have shown changes of oxidative stress levels in prefrontal cortex, cortical regions and cerebellum of exposed animals. These changes implicate synergistic and potentiated toxic potential of combinations of named drugs.

Item Type: Thesis (Diploma thesis)
Keywords: aspirin, warfarine, ginkgo (Ginkgo biloba), Centella asiatica, oxidative stress, brain
Supervisor: Đikić, Domagoj
Date: 2015
Number of Pages: 47
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 08 Mar 2016 11:58
Last Modified: 08 Mar 2016 11:58

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