The association between 5-HT1B serotonin receptor gene polymorphism and acute extrapyramidal side effects in haloperidol-treated patients with schizophrenia

Hrgovčić, Ana (2015) The association between 5-HT1B serotonin receptor gene polymorphism and acute extrapyramidal side effects in haloperidol-treated patients with schizophrenia. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Schizophrenia is a serious chronic psychiatric condition with neurobiological basis still largely unknown. Therapy consists of typical and atypical antipsychotic; however some patients develop side effects that severely affect treatment outcomes and lead to discontinuation of therapy and frequent relapse. Well known side effects of typical antipsychotics are acute (dystonia, parkinsonism, akathisia) and chronic (tardive dyskinesia) extrapyramidal side effects (EPS), while metabolic syndrome and weight gain are main side effects of atypical antipsychotics. Atypical antipsychotics differ from typical in higher affinity for serotonin 5-HT receptors and faster dissociation from dopamine D2 receptors. Findings on various interactions between serotonin and dopamine systems in the brain have raised questions about possible involvement of serotonin in EPS. Therefore, the aim of this research was to determine the possible association between rs13212041 polymorphism in the gene for the serotonin 5-HT1B receptor in patients with schizophrenia, with the development of acute EPS after treatment with typical antipsychotic drug haloperidol. The study found significant association of rs132120411 polymorphism in the gene coding for the serotonin 5-HT1B receptor with the development of akathisia in schizophrenia patients following haloperidol therapy. The results should help clinicians to individualize the pharmacotherapy and by preventing the unwanted side effects of antipsychotics to increase the treatment efficacy and quality of life of schizophrenia patients.

Item Type: Thesis (Diploma thesis)
Keywords: serotonin, dopamine, EPS, rs13212041, HTR1B
Supervisor: Švob Štrac, Dubravka
Co-supervisor: Hranilović, Dubravka
Date: 2015
Number of Pages: 50
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 08 Mar 2016 12:36
Last Modified: 08 Mar 2016 12:36
URI: http://digre.pmf.unizg.hr/id/eprint/4556

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