Association between LEPR gene 1019 polymorphism and the morphological characteristics in Roma population of Croatia

Jakopec, Martin (2015) Association between LEPR gene 1019 polymorphism and the morphological characteristics in Roma population of Croatia. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Many epidemiological researches have shown that obesity is an important risk factor for most of the chronical diseases of modern age. Leptin and leptin receptors are important regulators of nutritional status, energy usage and body fat distribution. Therefore, the objective of this research was to test the association of LEPR gene polymorphism 1019 with morphological indicators of nutritional status of Roma population living in Croatia. The Roma have been chosen for research because of high prevalence of obesity, type 2 diabetes and because they are an endogamous founder community where it is possible to determine specific associations between genotype and phenotype. Research was done on 401 adult persons, whom have undergone anthropometry and whose blood samples were taken for DNA analysis. Polymerase chain reaction followed by a restriction enzyme cleavage was used to determine the genotype. The association of categorical variables of nutritional status with genotype was tested by Pearson’s Chi2-test. The association of measured quantitative variables with genotype has been checked by variance analysis (ANOVA) with PostHoc test. To remove differences between sexes, an alignment has been made by creating „z-variables“ within each sex specifically. It has been shown that TT genotype of LEPR 1019 polymorphism is an important predictor of obesity in this population, and that it also has a major impact on central fat tissue accumulation in the male population.

Item Type: Thesis (Diploma thesis)
Keywords: leptin receptor gene, anthropometry, obesity, association study, Roma
Supervisor: Škarić Jurić, Tatjana
Co-supervisor: Kovačević, Goran
Date: 2015
Number of Pages: 48
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 09 Mar 2016 09:41
Last Modified: 09 Mar 2016 09:41
URI: http://digre.pmf.unizg.hr/id/eprint/4559

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