The expression of genes for beta-catenin and p53 in meningioma

Logara, Monika (2015) The expression of genes for beta-catenin and p53 in meningioma. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Meningiomas are primary tumors of the central nervous system. Beta-catenin is a cytoplasmic protein encoded by the CTNNB1 gene, it participates in the formation and maintenance of adherens junction and Wnt signaling pathway. Wnt signaling pathway plays an important role during embryonic development, specially in the development of the central nervous system. Disruption of Wnt signaling pathway may cause cells to favor process of tumorigenesis. Aberrant accumulation of beta-catenin is characteristic for different types of tumors. There is evidence that the Wnt signaling pathways and p53 are connected, and that wild-type p53 protein acts like inhibitor of Wnt signaling. In the present study we wanted to analyze the level of expression of beta-catenin and p53 in a sample of meningioma and determine their localization in tumor cells. We also sought to determine the association between these two proteins and explore whether Wnt signaling pathways and p53 are involved in the formation of meningiomas. Beta-catenin and p53 were detected by immunohistochemistry. The statistical analysis of expression levels showed that there is an inverse correlation between beta-catenin and p53 (P =-0.410; chi-square=0.002), which indicates that loss of p53 expression leads to aberrant acumulation of beta-catenin and activation of Wnt signaling pathway.

Item Type: Thesis (Diploma thesis)
Keywords: p53, beta-catetin, Wnt signaling pathway, meningioma
Supervisor: Pećina Šlaus, Nives
Co-supervisor: Matulić, Maja
Date: 2015
Number of Pages: 44
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 09 Mar 2016 09:49
Last Modified: 09 Mar 2016 09:49
URI: http://digre.pmf.unizg.hr/id/eprint/4560

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