Variability of major histocompatibility complex DRB1 class II genes in the wild boars (Sus scrofa) in the area of Medvednica

Balažin, Maja (2015) Variability of major histocompatibility complex DRB1 class II genes in the wild boars (Sus scrofa) in the area of Medvednica. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Major histocompatibility complex (MHC) plays a major role in initiating defense mechanisms of vertebrates. It is believed that some of the MHC loci are the most polymorphic in vertebrates. The variability of MHC genes affects population`s ability to defend itself from various pathogens. Major histocompatibility complex (MHC) of pigs is known as swine leukocyte antigen (SLA). Wild boar is considered one of the most widespread species. As host of many parasites it is suitable species for testing correlation between MHC haplotypes and susceptibility to diseases. The goal of the research was to discover imunogenetic diversity in the population of wild boars from Medvednica by analysis of DRB1 loci. In the examined sample of 49 individuals, seven alleles were found, one of them was new. According to the ratio of nonsynonymous and synonymous substitutions we have confirmed that the DRB1 locus isn`t under positive selection. An additional analysis of the effects of selection on individual codons showed us that only codon 48 is under the effect of positive selection. Results of this study will be used in further study of correlation between the MHC haplotypes and specific parasitic diseases of wild boars that will contribute to understanding of coevolution of the host and pathogen and maintenance of genetic diversity in animal populations.

Item Type: Thesis (Diploma thesis)
Keywords: Suidae, MHC, genetic variability, parasitic diseases
Supervisor: Galov, Ana
Co-supervisor: Arbanasić, Haidi
Date: 2015
Number of Pages: 44
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Silvana Šehić
Date Deposited: 23 Mar 2016 10:07
Last Modified: 23 Mar 2016 10:07
URI: http://digre.pmf.unizg.hr/id/eprint/4597

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