Analysis of kinship and detection of Kenny – Caffey syndrome in skeletons recovered from medieval grave in Dubrovnik area

Hajdinjak, Mateja (2013) Analysis of kinship and detection of Kenny – Caffey syndrome in skeletons recovered from medieval grave in Dubrovnik area. Diploma thesis, Faculty of Science > Department of Biology.

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Abstract

Skeletal remains of a woman and a child were found in a common medieval tomb during excavations at the archaeological site Sveti Petar Zvekovica near the city of Dubrovnik. Morphological analysis of skeletal remains showed that the woman had the main characteristics of the Kenny - Caffey syndrome, a rare congenital disorder of proportionate dwarfism, and the child had morphological features of the Klippel - Feil syndrome, another rare disorder. To answer the question whether the two skeletons belonged to a mother and a child, or if they were placed together in a common tomb because of their morphological features, we extracted DNA from skeletal remains and analyzed kinship using two commercial kits. Due to severe degradation of DNA and presence of inhibitors, we weren't able to confirm kinship nor disprove it and, also, we couldn't prove the Kenny - Caffey syndrome at the molecular level using allele – specific PCR.

Item Type: Thesis (Diploma thesis)
Keywords: congenital disorder, ancient DNA, inhibitor, polymorphism, DNA profile
Supervisor: Šlaus, Mario
Co-supervisor: Marijanović, Inga
Date: 2013
Number of Pages: 89
Subjects: NATURAL SCIENCES > Biology
Divisions: Faculty of Science > Department of Biology
Depositing User: Grozdana Sirotic
Date Deposited: 20 Feb 2014 14:06
Last Modified: 22 Sep 2014 10:57
URI: http://digre.pmf.unizg.hr/id/eprint/462

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